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The Binding of Isaac by Edmund McMillen takes about 12 hours to beat the main story, or roughly 117 hours to complete 100%.
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The Binding of Isaac is a randomly generated action RPG shooter with heavy rogue-like elements. Following Isaac on his journey players will find bizarre treasures that change Isaac's form giving him super human abilities and enabling him to fight off droves of mysterious creatures, discover secrets and fight his way to safety.